The Use of In Vitro Systems for Evaluating Immunotoxicity: The Report and Recommendations of an ECVAM Workshop
This is the report of aworkshop organised by the European Centre
for the Validation of Alternative Methods (ECVAM). ECVAM's
main goal, as defined in 1993 by its Scientific Advisory Committee,
is to promote the scientific and regulatory acceptance of alternative
methods that are of importance to the biosciences and
which replace, reduce or refine the use of laboratory animals. One
of the first priorities set by ECVAM was the implementation of
procedures that would enable it to become well informed about the
state-of-the-art of non-animal test development and validation, and
the potential for the possible incorporation of alternative tests into
regulatory procedures.
It was decided that this would be best achieved by the organization
of ECVAMworkshops on specific topics, at which small groups
of invited experts would review the current status of various types
of in vitro tests and their potential uses, andmake recommendations
about the best ways forward (Anonymous, 1994).
The workshop on "The use of in vitro systems for evaluating
Immunotoxicity" was held at ECVAM (Ispra), Italy, on 24th-26th
November 2003. The participants represented academia, national
organizations, international regulatory bodies and industry. The
aim of the workshop was to review the state-of-the-art in the field
of in vitro immunotoxicology, and to develop strategies towards the
replacement of in vivo testing. At the end of this report are listed the
recommendations that should be considered for prevalidation and
validation of relevant and reliable procedures, that could replace
the use of animals in chemical and cosmetics toxicity testing.
GENNARI Alessandra;
BRAUN Armin;
BAN Masarin;
CASATI Silvia;
CORSINI Emanuela;
DASTYCH Jaroslaw;
DESCOTES Jacques;
HOOGHE-PETERS Robert;
HARTUNG Thomas;
HOUSE Robert;
PALLARDY Marc;
PIETERS Raymond;
REID Lynnda;
TRYPHONAS Helen;
2007-02-22
TAYLOR & FRANCIS INC
JRC34072
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