Title: Interleukin 12 mediated prevention of Tumorigenicity in Murine Cell Lines derived from CD40L Transgenic Mice
Authors: GRIBALDO LAURAMALERBA IlariaDIODOVICH CristinaSACCO MARIA-GRAZIACOLLOTTA ANGELOELETTI BrighittaBASSI Loredana
Citation: EXPERIMENTAL AND MOLECULAR PATHOLOGY vol. 79 p. 236-243
Publisher: ACADEMIC PRESS LTD ELSEVIER SCIENCE LTD
Publication Year: 2005
JRC N°: JRC34154
URI: http://publications.jrc.ec.europa.eu/repository/handle/JRC34154
Type: Articles in periodicals and books
Abstract: Cells derived from superficial and deep lymph nodes of transgenic mice in which CD40L expression was deregulated were grown in vitro. After 3 months of interleukin 3 or interleukin 12 stimulation, the cells remained interleukin-independent, showed the same in vitro growth characteristics, but LIL3+ cells were tumorigenic when reinoculated in vivo in nude mice, whereas interleukin-12-treated cells did not induce tumors. Our cell lines could provide a useful model to study the perturbation of the homeostasis allowing us to elucidate the role of cytokines as modulators of differentiation in the lymphoproliferative disorders.
JRC Directorate:Institute for Health and Consumer Protection Historical Collection

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