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|Title:||Interleukin 12 mediated prevention of Tumorigenicity in Murine Cell Lines derived from CD40L Transgenic Mice|
|Authors:||GRIBALDO LAURA; MALERBA Ilaria; DIODOVICH Cristina; SACCO MARIA-GRAZIA; COLLOTTA ANGELO; ELETTI Brighitta; BASSI Loredana|
|Citation:||EXPERIMENTAL AND MOLECULAR PATHOLOGY vol. 79 p. 236-243|
|Publisher:||ACADEMIC PRESS LTD ELSEVIER SCIENCE LTD|
|Type:||Articles in periodicals and books|
|Abstract:||Cells derived from superficial and deep lymph nodes of transgenic mice in which CD40L expression was deregulated were grown in vitro. After 3 months of interleukin 3 or interleukin 12 stimulation, the cells remained interleukin-independent, showed the same in vitro growth characteristics, but LIL3+ cells were tumorigenic when reinoculated in vivo in nude mice, whereas interleukin-12-treated cells did not induce tumors. Our cell lines could provide a useful model to study the perturbation of the homeostasis allowing us to elucidate the role of cytokines as modulators of differentiation in the lymphoproliferative disorders.|
|JRC Directorate:||Institute for Health and Consumer Protection Historical Collection|
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