Interleukin 12 mediated prevention of Tumorigenicity in Murine Cell Lines derived from CD40L Transgenic Mice
Cells derived from superficial and deep lymph nodes of transgenic mice in which CD40L expression was deregulated were grown in vitro.
After 3 months of interleukin 3 or interleukin 12 stimulation, the cells remained interleukin-independent, showed the same in vitro growth
characteristics, but LIL3+ cells were tumorigenic when reinoculated in vivo in nude mice, whereas interleukin-12-treated cells did not induce
tumors.
Our cell lines could provide a useful model to study the perturbation of the homeostasis allowing us to elucidate the role of cytokines as
modulators of differentiation in the lymphoproliferative disorders.
GRIBALDO Laura;
MALERBA Ilaria;
DIODOVICH Cristina;
SACCO Maria-Grazia;
COLLOTTA Angelo;
ELETTI Brighitta;
BASSI Loredana;
2006-11-15
ACADEMIC PRESS LTD ELSEVIER SCIENCE LTD
JRC34154
https://publications.jrc.ec.europa.eu/repository/handle/JRC34154,
10.1016/j.yexmp.2005.08.006,
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