Proton activation analysis has been recently applied for the determination of stable isotopes of trace metals in blood plasma samples taken from volunteers during tracer kinetic studies.
The very low values of intestinal intake for some elements, like ruthenium, make the kinetics of excretion crucial for interpreting the bioassay data. Therefore, a procedure to process urine samples has been developed in order to have proper targets for the activation with protons. Preliminary tests with Ru-doped samples, conducted using the MC-40 Cyclotron at JRC Ispra, has confirmed the feasibility of the method. The minimum detectable concentrations, in the current operating conditions, are 16 ng 99Ru/ml and 0.5 ng 101Ru/ml.
VERONESE I.;
CANTONE M.C.;
GIUSSANI A.;
AROGUNJO A.;
ROTH P.;
HOELLRIEGL V.;
OEH U.;
HOLZWARTH Uwe;
ABBAS Kamel;
2007-04-12
SPRINGER
JRC34334
https://publications.jrc.ec.europa.eu/repository/handle/JRC34334,
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