Thiolated Polyethylene Oxide as Non-Fouling Element for Nano-Patterned Bio-Devices

This work describes the synthesis of a thiolated polyethylene oxide that self-assembles on gold to create a non-fouling surface. Thiolated polyethylene oxide was synthesized by reacting 16-mercaptohexadecanoic acid with polyethylene glycol mono methyl ether. The coverage of the thiolated polyethylene oxide on gold was studied by Cyclic Voltammetry, and the modified surfaces were characterized by X-ray photoelectron Spectroscopy and Ellipsometry. Protein resistance was assessed using Quartz Crystal Microbalance. Results showed a non-fouling character produced by the thiolated polyethylene oxide. The synthesized product was used as the passivation layer on nano-patterned surfaces consisting of arrayed nano-spots, fabricated by plasma based colloidal lithography. The specific adsorption of anti-bovine serum albumin in the mercaptohexadecanoic acid spots was verified by Atomic force Microscopy.

VIEIRA LISBOA Patricia;  VALSESIA Andrea;  COLPO Pascal;  GILLILAND Douglas;  CECCONE Giacomo;  PAPADOPOULOU Andri;  RAUSCHER Hubert;  RENIERO Fabiano;  GUILLOU Claude;  ROSSI Francois; 

2007-02-22

ELSEVIER SCIENCE BV

JRC34582

https://publications.jrc.ec.europa.eu/repository/handle/JRC34582,