Towards the Certification of the Purity of Calibrator Reference Materials for Thyroid Hormones: a Chicken and Egg Dilemma
The certification of the purity of CRMs intended for calibration, where no other certified material already exists for comparison raises principle questions on how to determine the purity of a "first" calibrant in the calibration hierarchy. We developed and certified two CRMs for their purity in thyroid hormones (thyroxine (thyroxine, T4) and 3,3',5-triiodothyronine (T3)) taking into consideration inorganic residues, residual solvents and organic impurities detectable by HPLC-UV and HPLC-MS. The approach we used aims to determine the purity of these two CRMs to the best of our knowledge and taking all scientific aspects properly into account for the estimation of an uncertainty related to the stated purity.
TOUSSAINT Brigitte;
SCHIMMEL Heinz;
KLEIN Christoph;
WIERGOWSKI Marek;
EMONS Hendrik;
2007-12-03
ELSEVIER SCIENCE BV
JRC34795
0021-9673,
http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6TG8-4MMFVRK-3&_user=4900406&_coverDate=07%2F13%2F2007&_rdoc=1&_fmt=&_orig=search&_sort=d&view=c&_acct=C000036252&_version=1&_urlVersion=0&_userid=4900406&md5=3b7f569c1841c9d0b78c185ed77a0f02,
https://publications.jrc.ec.europa.eu/repository/handle/JRC34795,
10.1016/j.chroma.2006.11.095,
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