Many biological subdisciplines that regularly assess dose-response relationships have identified an evolutionarily conserved process in which a low dose of a stressful stimulus activates an adaptive response that increases the resistance of the cell or organism to a moderate to severe level of stress. Due to a lack of frequent interaction among scientists in these many areas, there has emerged a broad range of terms that describe such dose-response relationships. This situation has become problematic because the different terms describe a family of similar biological responses (e.g., adaptive response, preconditioning, hormesis), adversely affecting interdisciplinary communication, and possibly even obscuring generalizable features and central biological concepts. With support from scientists in a broad range of disciplines, this article offers a set of recommendations we believe can achieve greater conceptual harmony in dose- response terminology, as well as better understanding and communication across the broad spectrum of biological disciplines.
CALABRESE Edward;
BACHMANN Kenneth A.;
BAILER A. John;
BOLGER P. Michael;
BORAK Jonathan;
CAI Lu;
CEDERGREEN Nina;
CHERIAN M. George;
CHIUEH Chuang C.;
CLARKSON Thomas W.;
COOK Ralph R.;
DIAMOND David M.;
DOOLITTLE David J.;
DORATO Michael A.;
DUKE Stephen O.;
FEINENDEGEN Ludwig;
GARDNER Donald E.;
HART Ronald W.;
HASTINGS Kenneth L.;
HAYES A. Wallace;
HOFFMANN George R.;
IVES John A.;
JAWOROWSKI Zbigniew;
JOHNSON Thomas E.;
JONAS Wayne B.;
KAMINSKI Norbert E.;
KELLER John G.;
KLAUNIG James E.;
KNUDSEN Thomas B.;
KOZUMBO Walter J.;
LETTIERI Teresa;
LIU Shu-Zheng;
MAISSEU Andre;
MAYNARD Kenneth I.;
MASORO Edward J.;
MCCLELLAN Roger O.;
MEHENDALE Harihara M.;
MOTHERSILL Carmel;
NEWLIN David B.;
NIGG Herbert N.;
OEHME Frederick W.;
PHALEN Robert F.;
PHILBERT Martin A.;
RATTAN Suresh I.S.;
RIVIERE Jim E.;
RODRICKS Joseph;
SAPOLSKY Robert M.;
SCOTT Bobby R.;
SEYMOUR Colin;
SINCLAIR David A.;
SMITH-SONNEBORN Joan;
SNOW Elizabeth T.;
SPEAR Linda;
STEVENSON Donald E.;
THOMAS Yolene;
TUBIANA Maurice;
WILLIAMS Gary M.;
MATTSON Mark P.;
2007-11-09
ACADEMIC PRESS INC ELSEVIER SCIENCE
JRC34982
0041-008X,
https://publications.jrc.ec.europa.eu/repository/handle/JRC34982,
10.1016/j.taap.2007.02.015,
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