Biological Stress Response Terminology: Integrating the Concepts of Adaptive Response and Preconditioning Stress Within a Hormetic Dose-Response Framework

Many biological subdisciplines that regularly assess dose-response relationships have identified an evolutionarily conserved process in which a low dose of a stressful stimulus activates an adaptive response that increases the resistance of the cell or organism to a moderate to severe level of stress. Due to a lack of frequent interaction among scientists in these many areas, there has emerged a broad range of terms that describe such dose-response relationships. This situation has become problematic because the different terms describe a family of similar biological responses (e.g., adaptive response, preconditioning, hormesis), adversely affecting interdisciplinary communication, and possibly even obscuring generalizable features and central biological concepts. With support from scientists in a broad range of disciplines, this article offers a set of recommendations we believe can achieve greater conceptual harmony in dose- response terminology, as well as better understanding and communication across the broad spectrum of biological disciplines.

CALABRESE Edward;  BACHMANN Kenneth A.;  BAILER A. John;  BOLGER P. Michael;  BORAK Jonathan;  CAI Lu;  CEDERGREEN Nina;  CHERIAN M. George;  CHIUEH Chuang C.;  CLARKSON Thomas W.;  COOK Ralph R.;  DIAMOND David M.;  DOOLITTLE David J.;  DORATO Michael A.;  DUKE Stephen O.;  FEINENDEGEN Ludwig;  GARDNER Donald E.;  HART Ronald W.;  HASTINGS Kenneth L.;  HAYES A. Wallace;  HOFFMANN George R.;  IVES John A.;  JAWOROWSKI Zbigniew;  JOHNSON Thomas E.;  JONAS Wayne B.;  KAMINSKI Norbert E.;  KELLER John G.;  KLAUNIG James E.;  KNUDSEN Thomas B.;  KOZUMBO Walter J.;  LETTIERI Teresa;  LIU Shu-Zheng;  MAISSEU Andre;  MAYNARD Kenneth I.;  MASORO Edward J.;  MCCLELLAN Roger O.;  MEHENDALE Harihara M.;  MOTHERSILL Carmel;  NEWLIN David B.;  NIGG Herbert N.;  OEHME Frederick W.;  PHALEN Robert F.;  PHILBERT Martin A.;  RATTAN Suresh I.S.;  RIVIERE Jim E.;  RODRICKS Joseph;  SAPOLSKY Robert M.;  SCOTT Bobby R.;  SEYMOUR Colin;  SINCLAIR David A.;  SMITH-SONNEBORN Joan;  SNOW Elizabeth T.;  SPEAR Linda;  STEVENSON Donald E.;  THOMAS Yolene;  TUBIANA Maurice;  WILLIAMS Gary M.;  MATTSON Mark P.; 

2007-11-09

ACADEMIC PRESS INC ELSEVIER SCIENCE

JRC34982

0041-008X,   

https://publications.jrc.ec.europa.eu/repository/handle/JRC34982,   

10.1016/j.taap.2007.02.015,