Incorporating In Vitro Alternative Methods for Developmental Neurotoxicity into International Hazard and Risk Assessment Strategies

This is the report of the first workshop on 'Incorporating In Vitro Alternative Methods for Developmental Neurotoxicity (DNT) Testing into International Hazard and Risk Assessment Strategies' held in Ispra, Italy on 19-21 April 2005. The workshop was hosted by the European Centre for the Validation of Alternative Methods (ECVAM) and jointly organized by ECVAM, the European Chemical Industry Council (CEFIC) and the Johns Hopkins University Center for Alternatives to Animal Testing (CAAT). The primary aim of the workshop was to identify and catalogue potential methods that could be used to assess how data from in vitro alternative methods could help to predict and identify DNT hazards. Working groups focused on two different aspects: (1) Details on the science available in the field of DNT, including discussions on the models available to capture the critical DNT mechanisms and processes, and (2) Policy and strategy aspects to assess the integration of alternative methods in a regulatory framework. This report summarises these discussions and details the recommendations and priorities for future work.

COECKE Sandra;  GOLDBERG Alan;  ALLEN Sandra;  BUZANSKA Leonora;  CALAMANDREI Gemma;  CROFTON Kevin;  HARENG L.;  HARTUNG Thomas;  KNAUT Holger;  HONEGGER Paul;  JACOBS Miriam;  LEIN Pamela;  LI Abby;  MUNDY William;  OWEN David;  SCHNEIDER Steffen;  SILBERGELD Ellen;  REUM Torsten;  TRNOVEC Tomas;  MONNET-TSCHUDI Florianne;  PRICE Anna; 

2007-06-19

US DEPT HEALTH HUMAN SCIENCES PUBLIC HEALTH SCIENCE

JRC35731

0091-6765,   

https://publications.jrc.ec.europa.eu/repository/handle/JRC35731,