The phage surface display technique was used to identify Borrelia burgdorferi antigens. By affinity selection with immunoglobulin G from pooled sera of six Lyme borreliosis (LB) patients, the ribosomal protein L25 was identified. The diagnostic value of L25 was investigated by an enzyme-linked immunosorbent assay, using sera from 80 LB patients and 75 controls, and the use of the protein resulted in a specificity of 99% and a 23% sensitivity, which qualify L25 as a useful antigen when combined with others.
MUELLER Markus;
BUNK Sebastian;
DITERICH Isabel;
WEICHEL Michael;
RAUTER Carolin;
HASSLER Dieter;
HERMANN Corinna;
CRAMERI Reto;
HARTUNG Thomas;
2007-02-19
AMER SOC MICROBIOLOGY
JRC36184
https://publications.jrc.ec.europa.eu/repository/handle/JRC36184,
10.1128/JCM.00371-06,
This document is only visible at the Commission level.
You are not authorized to publish or distribute it outside the European Commission.
This is a public document. You can share this publication.
Additional supporting files
| File name | Description | File type | |
|---|
