Identification of Borrelia Burgdorferi Ribosomal Protein L25 by the Phage Surface Display Method and Evaluation of the Protein's Value for Serodiagnosis
The phage surface display technique was used to identify Borrelia burgdorferi antigens. By affinity selection with immunoglobulin G from pooled sera of six Lyme borreliosis (LB) patients, the ribosomal protein L25 was identified. The diagnostic value of L25 was investigated by an enzyme-linked immunosorbent assay, using sera from 80 LB patients and 75 controls, and the use of the protein resulted in a specificity of 99% and a 23% sensitivity, which qualify L25 as a useful antigen when combined with others.
MUELLER Markus;
BUNK Sebastian;
DITERICH Isabel;
WEICHEL Michael;
RAUTER Carolin;
HASSLER Dieter;
HERMANN Corinna;
CRAMERI Reto;
HARTUNG Thomas;
2007-02-19
AMER SOC MICROBIOLOGY
JRC36184
https://publications.jrc.ec.europa.eu/repository/handle/JRC36184,
10.1128/JCM.00371-06,
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