Review of Data Sources, QSARs and Integrated Testing Strategies for Aquatic Toxicity
This review collects information on sources of aquatic toxicity data and
computational tools for estimation of chemical toxicity aquatic to aquatic organisms,
such as expert systems and quantitative structure-activity relationship (QSAR)
models. The review also captures current thinking of what constitutes an integrated
testing strategy (ITS) for this endpoint. The emphasis of the review is on the
usefulness of the models and for the regulatory assessment of chemicals, particularly
for the purposes of the new European legislation for the Registration, Evaluation,
Authorisation and Restriction of Chemicals (REACH), which entered into force on 1
June 2007. Effects on organisms from three trophic levels (fish, Daphnia and algae)
were subject of this review. In addition to traditional data sources such as databases,
papers publishing experimental data are also identified. Models for narcoses, general
(global) models as well as models for specific chemical classes and mechanisms of
action are summarised. Where possible, models were included in a form allowing
reproduction without consultation with the original paper. This review builds on work
carried out in the framework of the REACH Implementation Projects, and was
prepared as a contribution to the EU funded Integrated Project, OSIRIS.
NETZEVA Tatiana;
PAVAN Manuela;
WORTH Andrew;
2007-11-06
OPOCE
JRC40402
1018-5593,
EUR 22943 EN,
Additional supporting files
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