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http://publications.jrc.ec.europa.eu/repository/handle/JRC41945| Title: | Gemcitabine Radiosensitizes Multiple Myeloma Cells to Low LET, but not High LET, Irradiation |
| Authors: | SUPIOT S.; THILLAYS F.; RIO E.; GOUARD S.; MORGENSTERN ALFRED; BRUCHERTSEIFER FRANK; MAHE M. A.; CHATAL J. F.; DAVODEAU F.; CHEREL M. |
| Citation: | RADIOTHERAPY AND ONCOLOGY vol. 83 p. 97-101 |
| Publisher: | ELSEVIER IRELAND LTD |
| Publication Year: | 2007 |
| JRC N°: | JRC41945 |
| ISSN: | 0167-8140 |
| URI: | http://publications.jrc.ec.europa.eu/repository/handle/JRC41945 |
| DOI: | 10.1016/j.radonc.2007.02.005 |
| Type: | Articles in periodicals and books |
| Abstract: | The radiosensitizing properties of gemcitabine in relation to low Linear Energy Transfer (LET) particles (Cobalt 60) and high-LET particles (alpha-RIT 213Bi-radiolabeled CHX-DTPA-B-B4) were analyzed. Three multiple myeloma cell lines (LP1, RPMI 8226, U266) were irradiated with or without 10 nM gemcitabine 24 h prior to radiation. Gemcitabine led to radiosensitization of LP1 and U266 cells with low-LET (Radiation Enhancement Ratio: 1.55 and 1.49, respectively) but did not radiosensitize any cell line when combined with high-LET. |
| JRC Directorate: | Nuclear Safety and Security |
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