Gemcitabine Radiosensitizes Multiple Myeloma Cells to Low LET, but not High LET, Irradiation
The radiosensitizing properties of gemcitabine in relation to low Linear Energy Transfer (LET) particles (Cobalt 60) and
high-LET particles (alpha-RIT 213Bi-radiolabeled CHX-DTPA-B-B4) were analyzed. Three multiple myeloma cell lines (LP1,
RPMI 8226, U266) were irradiated with or without 10 nM gemcitabine 24 h prior to radiation. Gemcitabine led to
radiosensitization of LP1 and U266 cells with low-LET (Radiation Enhancement Ratio: 1.55 and 1.49, respectively) but
did not radiosensitize any cell line when combined with high-LET.
SUPIOT S.;
THILLAYS F.;
RIO E.;
GOUARD S.;
MORGENSTERN Alfred;
BRUCHERTSEIFER Frank;
MAHE M. A.;
CHATAL J. F.;
DAVODEAU F.;
CHEREL M.;
2007-12-04
ELSEVIER IRELAND LTD
JRC41945
0167-8140,
https://publications.jrc.ec.europa.eu/repository/handle/JRC41945,
10.1016/j.radonc.2007.02.005,
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