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|Title:||Gemcitabine Radiosensitizes Multiple Myeloma Cells to Low LET, but not High LET, Irradiation|
|Authors:||SUPIOT S.; THILLAYS F.; RIO E.; GOUARD S.; MORGENSTERN ALFRED; BRUCHERTSEIFER FRANK; MAHE M. A.; CHATAL J. F.; DAVODEAU F.; CHEREL M.|
|Citation:||RADIOTHERAPY AND ONCOLOGY vol. 83 p. 97-101|
|Publisher:||ELSEVIER IRELAND LTD|
|Type:||Articles in periodicals and books|
|Abstract:||The radiosensitizing properties of gemcitabine in relation to low Linear Energy Transfer (LET) particles (Cobalt 60) and high-LET particles (alpha-RIT 213Bi-radiolabeled CHX-DTPA-B-B4) were analyzed. Three multiple myeloma cell lines (LP1, RPMI 8226, U266) were irradiated with or without 10 nM gemcitabine 24 h prior to radiation. Gemcitabine led to radiosensitization of LP1 and U266 cells with low-LET (Radiation Enhancement Ratio: 1.55 and 1.49, respectively) but did not radiosensitize any cell line when combined with high-LET.|
|JRC Directorate:||Nuclear Safety and Security|
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