The radiosensitizing properties of gemcitabine in relation to low Linear Energy Transfer (LET) particles (Cobalt 60) and
high-LET particles (alpha-RIT 213Bi-radiolabeled CHX-DTPA-B-B4) were analyzed. Three multiple myeloma cell lines (LP1,
RPMI 8226, U266) were irradiated with or without 10 nM gemcitabine 24 h prior to radiation. Gemcitabine led to
radiosensitization of LP1 and U266 cells with low-LET (Radiation Enhancement Ratio: 1.55 and 1.49, respectively) but
did not radiosensitize any cell line when combined with high-LET.
SUPIOT S.;
THILLAYS F.;
RIO E.;
GOUARD S.;
MORGENSTERN Alfred;
BRUCHERTSEIFER Frank;
MAHE M. A.;
CHATAL J. F.;
DAVODEAU F.;
CHEREL M.;
2007-12-04
ELSEVIER IRELAND LTD
JRC41945
0167-8140,
https://publications.jrc.ec.europa.eu/repository/handle/JRC41945,
10.1016/j.radonc.2007.02.005,
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