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dc.contributor.authorMARAFANTE Erminioen_GB
dc.date.accessioned2010-02-25T16:36:03Z-
dc.date.available1995-03-15en_GB
dc.date.available2010-02-25T16:36:03Z-
dc.date.issued1987en_GB
dc.date.submitted1986-06-09en_GB
dc.identifier.citationToxicology Letters vol. 37 p. 41-46en_GB
dc.identifier.urihttp://publications.jrc.ec.europa.eu/repository/handle/JRC4202-
dc.description.abstractTHE EFFECTS OF SIX WEEKS FEEDING WITH DIETS LOW IN METHIONINE, CHOLINE, METHIONINE AND CHOLINE, OR PROTEINS ON THE BIOTRANSFORMATION AND RETENTION OF 76AS-LABELLED ARSENITE (0.4 MG AS/KG BODY WEIGHT) IN RABBITS HAVE BEEN STUDIED. ALL TEST DIETS CAUSED ADEPRESSION OF THE METHYLATION OF THE ADMINISTRATED ARSENITE, AND A SIGNIFICANTLY DECREASE IN THE URINARY EXCRETION OF 76AS-DIMETHYLARSINIC ACID, THE MAIN METABOLITE OF INORGANIC ARSENIC. THIS GAVE RISE TO AN INCREASED RETENTION OF ARSENIC IN THE TISSUES, AT 3 DAYS AFTER THE ARSENITE ADMINISTRATION MAINLY IN THE LIVER KIDNEYS, LUNGS AND TESTES. THIS EFFECT WAS MOST MARKED IN RABBITS FED A DIET DEPRIVED IN BOTH METHIONINE AND CHOLINE. THE TEST DIETS ALSO CAUSED A SPECIFIC INCREASE OF THE ARSENIC CONCENTRATION IN THE LIVER MICROSOMES, WHICH DOES NOT OCCUR FOLLOWING CHEMICALLY INDUCED DEPRESSION OF THE ARSENIC METHYLATION. THE RESULTS INDICATE THAT SUBJECTS WITH A LOW NUTRITIONAL STATUS, ESPECIALLY LOW PROTEIN INTAKES, HAVE A LOWER CAPACITY OF METHYLATING AND THEREBY DETOXIFYING INORGANIC ARSENIC, WHICH WOULD RENDER THEM MORE SENSITIVE TO ARSENIC EXPOSURE. KEY WORDS: ARSENITE, BIOTRANSFORMATION, METHYLATION, MALNUTRITION, METHIONINE, CHOLINEen_GB
dc.description.sponsorshipNA-NOT AVAILABLEen_GB
dc.format.mediumPrinteden_GB
dc.languageENGen_GB
dc.relation.ispartofseriesJRC4202en_GB
dc.titleEffects of Low Dietary Intake of Methionine, Choline and Protein on the Biotransformation of Arsenite in the Rabbiten_GB
dc.typeArticles in periodicals and booksen_GB
JRC Directorate:Joint Research Centre Historical Collection

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