Experimental Study of the Influence of Ar/H2 Microwave Discharges on Lipid A
This paper discusses the influence of microwave discharge plasmas on Lipid A, one of the most problematic compounds from the point of view of conventional decontamination methods.
The effect of microwave discharges produced in different Ar/H2 mixtures on Lipid A films has been studied by means of both biological tests and materials characterisation methods (FT-IR and ToF-SIMS spectroscopy) in order to identify the main mechanisms leading to the suppression of their pyrogenicity. From the results obtained, it is concluded that most probably chemical modifications, namely the removal of long carboxylic acid chains and mineralisation of the organo-phosphate group, are responsible for Lipid A depyrogenation.
KYLIAN Ondrej;
HASIWA Marina;
GILLILAND Douglas;
ROSSI Francois;
2008-02-13
WILEY-V C H VERLAG GMBH
JRC42238
1612-8850,
https://publications.jrc.ec.europa.eu/repository/handle/JRC42238,
10.1002/ppap.200700093,
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