Review of Data Sources, QSARs and Integrated Testing Strategies for Skin Sensitisation
This review collects information on sources of skin sensitisation data and computational tools for the estimation of skin sensitisation potential, such as expert systems and (quantitative) structure-activity relationship (QSAR) models. The review also captures current thinking of what constitutes an integrated testing strategy (ITS) for this endpoint. The emphasis of the review is on the usefulness of the models for the regulatory assessment of chemicals, particularly for the purposes of the new European legislation for the Registration, Evaluation, Authorisation and Restriction of CHemicals (REACH), which entered into force on 1 June 2007. Since there are no specific databases for skin sensitisation currently available, a description of experimental data found in various literature sources is provided. General (global) models, models for specific chemical classes and mechanisms of action and expert systems are summarised. This review was prepared as a contribution to the EU funded Integrated Project, OSIRIS.
PATLEWICZ Grace;
WORTH Andrew;
2008-02-06
OPOCE
JRC43068
1018-5593,
EUR 23225 EN,
https://publications.jrc.ec.europa.eu/repository/handle/JRC43068,
Additional supporting files
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