An Evaluation of Performance Standards and Non-Radioactive Endpoints for the Local Lymph Node Assay
A Workshop on Alternative Endpoints for the Local Lymph Node Assay was held at ECVAM (Ispra, Italy) on 25-27 September 2007, under the chairmanship of David Basketter. The workshop was attended by experts from academia, industry, national organisation, and national and international validation authorities. At present, the local lymph node assay (LLNA) uses radiolabelled thymidine as part of the standard protocol. The aim of the workshop was to review the state of the art of methods using non-radioactive endpoints for the LLNA and to consider Performance Standards for their eventual assessment. At the end of the report are listed the recommendations that should be considered for progressing towards validation of relevant and reliable methods
BASKETTER David;
COCKSHOTT Amanda;
CORSINI Emanuela;
GERBERICK Frank;
IDEHARA Kenji;
KIMBER Ian;
VAN LOVEREN Henk;
MATHESON Johanna;
MEHLING Annette;
OMORI Takashi;
ROVIDA Maria;
SOZU Takashi;
TAKEYOSHI Masahiro;
CASATI Silvia;
2008-06-13
FRAME
JRC43624
0261-1929,
https://publications.jrc.ec.europa.eu/repository/handle/JRC43624,
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