Neural In Vitro Culture on Microelectrode Arrays (MEAs) as a Biosensor for Toxins and Neurotoxins Detection
Recently in vitro systems are widely used for assessment of toxicological and pharmaceutical properties of chemicals. The latest developments in the field on in vitro toxicology and pharmacology demands a new assays focused on endpoints strictly related to the tissue specific functions. One of such methods, based on electrophysiological measurements of spontaneous activity from planar neural structure using microelectrode arrays (MEA) will be presented in this paper. This type of biosensor is very sensitive to the neurotoxins, relatively stable and reproducible and suitable for long term monitoring (up to 9 months).
SOBANSKI Tomasz;
HOGBERG Helena;
WHELAN Maurice;
PRICE Anna;
2008-08-12
Sigma-Not
JRC44283
0033-2089,
https://publications.jrc.ec.europa.eu/repository/handle/JRC44283,
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