Determination of method trueness, or, in its negative term, method bias is generally recognised as intrinsic part of method validation. However, different viewpoints still exists on how to estimate a potential bias, whether to correct for a potential bias and how to accomodate the bias and its uncertainty in the uncertainty budget for a particular measurement. Base don the scientified literature as well as guidance documents from international bodies (ISO, IUPAC, Eurachem, ICH, APLAC etc.) this review concludes that results should generally be corrected from know bias/incomplete recovery. The uncertainty of the bias forms an intrinsic part of the measurement uncertainty, even when no significant bias was observed.
LINSINGER Thomas;
2008-11-11
ELSEVIER SCIENCE LONDON
JRC44567
0165-9936,
https://publications.jrc.ec.europa.eu/repository/handle/JRC44567,
10.1016/j.trac.2008.08.013,
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