Please use this identifier to cite or link to this item:
|Title:||Poly(N-isopropylacrylamide) Grafted on Plasma-Activated Poly(ethylene oxide): Thermal Response and Interaction With Proteins|
|Authors:||BRETAGNOL Frederic; MANNELLI Ilaria; SIRGHI Lucel; VALSESIA Andrea; CECCONE Giacomo; GILLILAND Douglas; LANDFESTER K.; RAUSCHER Hubert; ROSSI Francois; HEINZ P.|
|Citation:||LANGMUIR vol. 24 no. 12 p. 6166-6175|
|Publisher:||AMER CHEMICAL SOC|
|Type:||Articles in periodicals and books|
|Abstract:||Thermoresponsive polymer layers offer the possibility of preparing smart surfaces with properties that are switchable through a phase transition, usually close to the lower critical solution temperature of the polymer. In particular, poly(N-isopropylacrylamide) (pNIPAM) has gained a great deal of attention because it has such a phase transition in a physiologically interesting temperature range. We have prepared ultrathin thermoresponsive coatings by grafting pNIPAM on a plasma-CVD-deposited, poly(ethylene oxide)-like polymer substrate that was activated in an Ar plasma discharge to initiate the grafting. The presence and integrity of pNIPAM was verified by XPS and ToF-SIMS, and a dramatic change in the wettability during the phase transition was identified by temperature-dependent contact angle measurements. The transition from the hydrated to the collapsed conformation was analyzed by temperature-dependent QCM measurements and by AFM. An unusual, reversible behavior of the viscoelastic properties was seen directly at the phase transition from the swollen to the collapsed state. The phase transition leads to a switching from protein repulsion to a state that allows the adsorption of proteins.|
|JRC Directorate:||Institute for Health and Consumer Protection Historical Collection|
Files in This Item:
There are no files associated with this item.
Items in repository are protected by copyright, with all rights reserved, unless otherwise indicated.