Proteins are synthesized as linear polymers which develop biological activity as a result of folding into characteristics three-dimensional structures. Determination of the three-dimensional structures of all existing proteins is what lies within the scope of research defined as structural proteomics. Structural proteomics impacts greatly on basic research, providing information necessary to understand the relationship between protein sequence, structure, mechanism of action and function. It has also taken centre stage in biotechnological industry since structural knowledge of protein domains responsible for biological activity has become common starting point for drug design. The article summarizes the key stages in progressing through the structural proteomics projects pipelines, from target selection through protein sample preparation, structure determination by X-ray crystallography or NMR, structure prediction, to structure-based functional study of the target proteins.
RZYCHON Malgorzata;
SILBERRING Jerzy;
KRAJ Agnieszka;
2011-01-27
Wiley
JRC47226
978-0-470-05535-9,
https://publications.jrc.ec.europa.eu/repository/handle/JRC47226,
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