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dc.contributor.authorRZYCHON Malgorzataen_GB
dc.contributor.editorSILBERRING Jerzyen_GB
dc.contributor.editorKRAJ Agnieszkaen_GB
dc.date.accessioned2012-04-17T19:49:01Z-
dc.date.available2011-01-27en_GB
dc.date.available2012-04-17T19:49:01Z-
dc.date.created2011-01-21en_GB
dc.date.issued2008en_GB
dc.date.submitted2008-08-19en_GB
dc.identifier.isbn978-0-470-05535-9en_GB
dc.identifier.urihttp://publications.jrc.ec.europa.eu/repository/handle/JRC47226-
dc.description.abstractProteins are synthesized as linear polymers which develop biological activity as a result of folding into characteristics three-dimensional structures. Determination of the three-dimensional structures of all existing proteins is what lies within the scope of research defined as structural proteomics. Structural proteomics impacts greatly on basic research, providing information necessary to understand the relationship between protein sequence, structure, mechanism of action and function. It has also taken centre stage in biotechnological industry since structural knowledge of protein domains responsible for biological activity has become common starting point for drug design. The article summarizes the key stages in progressing through the structural proteomics projects pipelines, from target selection through protein sample preparation, structure determination by X-ray crystallography or NMR, structure prediction, to structure-based functional study of the target proteins.en_GB
dc.description.sponsorshipJRC.DG.D.2-Reference materialsen_GB
dc.format.mediumPrinteden_GB
dc.languageENGen_GB
dc.publisherWileyen_GB
dc.relation.ispartofseriesJRC47226en_GB
dc.titleStructural Proteomics - Chapter 10.2en_GB
dc.typeArticles in periodicals and booksen_GB
JRC Directorate:Health, Consumers and Reference Materials

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