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dc.contributor.authorWITTIG Andreaen_GB
dc.contributor.authorMICHEL Jeanen_GB
dc.contributor.authorMOSS Raymonden_GB
dc.contributor.authorSTECHER-RASMUSSEN Finnen_GB
dc.contributor.authorARLINGHAUS Heinrichen_GB
dc.contributor.authorBENDEL Peteren_GB
dc.contributor.authorMAURI Pierluigien_GB
dc.contributor.authorALTIERI Saverioen_GB
dc.contributor.authorHILGER Ralfen_GB
dc.contributor.authorSALVADORI Pieroen_GB
dc.contributor.authorMENICHETTI Lucaen_GB
dc.contributor.authorZAMENHOF Roberten_GB
dc.contributor.authorSAUERWEIN Wolfgangen_GB
dc.date.accessioned2010-02-25T15:51:03Z-
dc.date.available2009-12-10en_GB
dc.date.available2010-02-25T15:51:03Z-
dc.date.created2009-12-08en_GB
dc.date.issued2008en_GB
dc.date.submitted2008-10-21en_GB
dc.identifier.citationCRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY vol. 68 no. 1 p. 66-90en_GB
dc.identifier.issn1040-8428en_GB
dc.identifier.urihttp://www.croh-online.com/issues/contents?issue_key=S1040-8428(08)X0009-5en_GB
dc.identifier.urihttp://publications.jrc.ec.europa.eu/repository/handle/JRC48341-
dc.description.abstractBoron Neutron Capture Therapy (BNCT) is based on the ability of the stable isotope 10B to capture neutrons, which leads to a nuclear reaction producing an alpha- and a 7Li-particle, both having a high biological effectiveness and a very short range in tissue, being limited to approximately one cell diameter. This opens the possibility for a highly selective cancer therapy. BNCT strongly depends on the selective uptake of 10B in tumor cells and on its distribution inside the cells. The chemical properties of boron and the need to discriminate different isotopes make the investigation of the concentration and distribution of 10B a challenging task. The most advanced techniques to measure and image boron are described, both invasive and non-invasive. The most promising approach for further investigation will be the complementary use of the different techniques to obtain the information that is mandatory for the future of this innovative treatment modality.en_GB
dc.description.sponsorshipJRC.F.7-Energy systems evaluationen_GB
dc.format.mediumPrinteden_GB
dc.languageENGen_GB
dc.publisherELSEVIER SCIENCE INCen_GB
dc.relation.ispartofseriesJRC48341en_GB
dc.titleBoron Analysis and Boron Imaging in Biological Materials for Boron Neutron Capture Therapy (BNCT)en_GB
dc.typeArticles in periodicals and booksen_GB
dc.identifier.doi10.1016/j.critrevonc.2008.03.004en_GB
JRC Directorate:Energy, Transport and Climate

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