Production of 230U/226Th for Targeted Alpha Therapy via Proton Irradiation of 231Pa
230U and its daughter nuclide 226Th are novel therapeutic nuclides for application in targeted r-therapy of
cancer. We have investigated the feasibility of producing 230U/226Th via proton irradiation of 231Pa according
to the reaction 231Pa(p,2n)230U. The experimental excitation function for this reaction is reported for the
first time. Cross sections were measured using thin targets of 231Pa prepared by electrodeposition and 230U
yields were analyzed using r-spectrometry. Beam parameters (energy and intensity) were determined both
by calculation using a mathematical model based on measured beam orbits and beam current integrator and
by parallel monitor reactions on copper foils using highresolution ¿-spectrometry and IAEA recommended
cross-section data. The measured cross sections are in good agreement with model calculations using the
EMPIRE-II code and are sufficiently high for the production of 230U/226Th in clinically relevant amounts.
A highly effective separation process was developed to isolate clinical grade 230U from irradiated protactinium
oxide targets. Product purity was assessed using r- and ¿-spectrometry as well as ICPMS.
MORGENSTERN Alfred;
LEBEDA O.;
STURSA J.;
BRUCHERTSEIFER Frank;
CAPOTE R.;
MCGINLEY John;
RASMUSSEN Gert;
SIN M.;
ZIELINSKA B.;
APOSTOLIDIS Christos;
2008-11-20
AMER CHEMICAL SOC
JRC48532
0003-2700,
http://pubs.acs.org/doi/pdf/10.1021/ac801304c?cookieSet=1,
https://publications.jrc.ec.europa.eu/repository/handle/JRC48532,
10.1021/ac801304c,
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