The purpose of the guest editorial (1), ¿Developmental and reproductive toxicity testing: a potted history¿, is not clear to me. It described and justified the current situation in reproductive toxicity testing in various regulatory frameworks, but did not offer a critical assessment what is really needed to provide reliable data for safety assessment. It merely showed the historical development of regulatory guidelines and guidance. However, there is now a need to critically consider whether the testing paradigm is satisfactory, by retrospectively analysing the existing data before applying the cuurent scheme to large toxicological screening programmes, such as that represented by the EU REACH system.
BREMER Susanne;
2020-01-07
FRAME
JRC49393
0261-1929 (online),
https://publications.jrc.ec.europa.eu/repository/handle/JRC49393,
10.1177/026119290803600617 (online),
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