The production and certification of ERM-DA472/IFCC, a new reference material certified for C-reactive protein (CRP), is described. ERM-DA472/IFCC was characterised using the reference material ERM-DA470 as calibrant. This achieved using a value transfer protocol that can be considered as a reference procedure. the principles used to measure the CRP concentration were immunonephelometry and immunoturbidimetry. The measurements were performed with different platform/reagent combinations (Abbott, Beckmann Immage, BN II, different Hitachi instruments, and Olympus AU640). In total 8 laboratories participated in the value assignment. The certified CRP mass concentration is 41.8 mg/L, the expanded uncertainty (k = 2) 2.5 mg/L.
ZEGERS Ingrid;
CHAROUD-GOT Jean;
RZYCHON Malgorzata;
TRAPMANN Stefanie;
SCHIMMEL Heinz;
EMONS Hendrik;
SCHREIBER Wiebke;
SHELDON Joanna;
LINSTEAD Sarah;
MERLINI Giampaolo;
2009-02-12
OPOCE
JRC50108
978-92-79-11326-0,
1018-5593,
EUR 23756 EN,
OP LA-NA-23756-EN-C,
https://publications.jrc.ec.europa.eu/repository/handle/JRC50108,
10.2787/21201,
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