To analyze how toxic effects propagate from molecular to population level, a simple model of a circadian oscillator has been coupled with a cyanobacteria growth model. It has been assumed that the circadian oscillator synchronizes with light-dark environmental conditions and toxicants affect this synchronization reducing the population growth. Then dose-response curves have been developed. The results evidence that to understand toxic effects we have to focus our study on the interactions that a certain compound may have with proteins, and/or DNA, since the result of these interactions will determine the final mode of action at macroscopic level. Therefore an intermediate step for assessing toxic effects has been proposed.
ZALDIVAR COMENGES Jose';
2009-03-04
OPOCE
JRC50491
978-92-79-11603-2,
1018-5593,
EUR 23772 EN,
OP LB-NA-23772-EN-C,
https://publications.jrc.ec.europa.eu/repository/handle/JRC50491,
10.2788/82036,
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