Salts as a Source of Metals in Dialysis Fluids: an Assessment Study by Means of Neutron Activation Analysis

THIRTY-NINE TRACE METALS WERE DETERMINED BY NEUTRON ACTIVATION ANALYSIS (NAA) IN NINE SALTS FROM DIFFERENT EUROPEAN PRODUCERS, SUCH AS GLUCOSE, NAC1, KC1, CAC12, MGC12, NA-LACTATE, NA-ACETATE, NAHCO3 AND NAOH, USED IN THE PREPA- RATION OF DIALYSIS FLUIDS. METAL CONCENTRATIONS OF THE ELEMENTS VERY WIDELY FROM LESS THAN ONE NG/G TO SOME /UG/G. THE DATA WERE USED TO ASSESS THE POTEN- TIAL METAL CONTRIBUTION OF THE SALTS TO A HYPOTHETICAL DIALYSIS FLUID. A COM- PARISON OF THESE CALCULATIONS WITH NAA OF COMMERCIAL HEMODIALYSIS SOLUTIONS AND WATER USED FOR THEIR PREPARATION SUGGESTS THAT SALTS ARE THE MAIN SOURCE OF METAL CONTAMINATION OF THE DIALYSATE. DESPITE THIS, THE CHEMICAL PURITY OF THE SALTS ANALYSED CAN BE CONSIDERED GOOD AND IT WOULD BE UNREALISTIC TO EXPECT A CLEARLY BETTER CHEMICAL QUALITY ON THE COMMERCIAL SCALE. THUS, IN ORDER TO PROTECT THE HEALTH OF DIALYSIS PATIENTS AGAINST ABNORMAL METAL EXPOSURE, TOXI- COLOGICAL RESEARCH DIRECTED TOWARDS THE ESTIMATION OF THE EFFECTIVE DAILY METAL EXPOSURE AND THE DETERMINATION OF POSSIBLE METAL OVERLOADS IN DIALYSIS PATIENTS IS NECESSARY

SABBIONI Enrico;  PIETRA Romano;  BERLIN A.;  UBERTALLI Livio;  SPEZIALI M.;  BARBESTI S.; 

1995-03-15

JRC5086

https://publications.jrc.ec.europa.eu/repository/handle/JRC5086,