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dc.contributor.authorSCHNEIDER Klausen_GB
dc.contributor.authorSCHWARZ Markusen_GB
dc.contributor.authorBURKHOLDER Irisen_GB
dc.contributor.authorKOPP-SCHNEIDER Annetteen_GB
dc.contributor.authorEDLER Lutzen_GB
dc.contributor.authorKINSNER-OVASKAINEN Agnieszkaen_GB
dc.contributor.authorHARTUNG Thomasen_GB
dc.contributor.authorHOFFMANN Sebastianen_GB
dc.date.accessioned2010-02-25T17:04:40Z-
dc.date.available2009-10-02en_GB
dc.date.available2010-02-25T17:04:40Z-
dc.date.created2009-09-25en_GB
dc.date.issued2009en_GB
dc.date.submitted2009-03-29en_GB
dc.identifier.citationTOXICOLOGY LETTERS vol. 189 no. 2 p. 138-144en_GB
dc.identifier.issn0378-4274en_GB
dc.identifier.urihttp://www.elsevier.com/locate/toxleten_GB
dc.identifier.urihttp://publications.jrc.ec.europa.eu/repository/handle/JRC51252-
dc.description.abstractEvaluation of the reliability of toxicological data is of key importance for regulatory decision-making. In particular, the new EU Regulations concerning the Registration, Evaluation, Authorisation and Restriction of Chemicals (REACH) and Classification and Labelling (CLP) according to the new Globally Harmonised System (GHS) rely on the integration of all available toxicological information. The so-called Klimisch categories, although well established and widely used, lack detailed criteria for assigning data quality to categories. A software-based tool (ToxRTool) was developed within the context of a project funded by the European Commission to provide comprehensive criteria and guidance for reliability evaluations of toxicological data. It is applicable to various types of experimental data, endpoints and studies (study reports, peer-reviewed publications) and leads to the assignment to Klimisch categories 1, 2 or 3. The tool aims to increase transparency and to harmonise approaches of reliability assessment. The tool consists of two parts, one to evaluate in vivo and one to evaluate in vitro data. The prototypes of the tool were tested in two independent inter-rater experiments. This approach allowed the analysis of the performance of the tool in practice and the identification and minimisation of sources of heterogeneity in evaluation results. The final version, ToxRTool, is publicly available for testing and use.en_GB
dc.description.sponsorshipJRC.I.3-In-vitro methodsen_GB
dc.format.mediumCD-ROMen_GB
dc.languageENGen_GB
dc.publisherELSEVIER IRELAND LTDen_GB
dc.relation.ispartofseriesJRC51252en_GB
dc.titleToxRTool, a new tool to assess the reliability of toxicological dataen_GB
dc.typeArticles in periodicals and booksen_GB
dc.identifier.doi10.1016/j.toxlet.2009.05.013en_GB
JRC Directorate:Institute for Health and Consumer Protection Historical Collection

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