Radio-activation of TiO2 nanoparticles for use in nanotoxicology studies, and as a model substance for activation of pharmaceutically relevant nanoparticles
Radiolabelling of manufactured nanoparticles is of interest for the development of innovative radio-therapeutic applications as well as for biodistribution and toxicological studies concerning possible adverse health effects following the large scale industrial use of such materials. However, activation procedures using charged particle beams necessitate a careful examination of possible structural and chemical changes of the nanoparticles that might alter their biological effect. The purpose of this study was to determine if TiO2 nanoparticles can be activated to suitable levels by high energy proton irradiation without causing significant structural damage to the nanoparticle matrix, and whether the activated nanoparticles behave in a biologically similar fashion to the non-activated material.
GIBSON Peter;
DEL TORCHIO Riccardo;
SIMONELLI Federica;
CYDZIK Izabela;
HOLZWARTH Uwe;
ABBAS Kamel;
FARINA M.;
2010-01-13
JOHN WILEY & SONS LTD
JRC53213
0362-4803,
https://publications.jrc.ec.europa.eu/repository/handle/JRC53213,
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