Literature reports of the efficacy of para-sulfonatocalix[6]- and calix[8]-arenes as U(VI) complexants indicated that they might be useful for in vivo chelation of the novel therapeutic alpha-emitter 230U. We have studied the complexation of U(VI) with para-sulfonatocalix[6]arene and para-sulfonatocalix[8]-arene by time resolved laser induced fluorescence spectroscopy and using competition methods with
Chelex resin and 4-(2-pyridylazo)resorcinol in simplified and in biological media. New thermodynamic parameters describing the stability of U(VI)-para-sulfonatocalix[n]arene [n = 6, 8] complexes were obtained. Although the interactions are strong, the complexes do not exhibit sufficient stability to compete with carbonate ions and serum proteins for complexation of U(VI) under physiological
MONTAVON Gilles;
REPINC Urska;
APOSTOLIDIS Christos;
BRUCHERTSEIFER Frank;
ABBAS Kamel;
MORGENSTERN Alfred;
2010-01-20
ROYAL SOC CHEMISTRY
JRC54900
1477-9226,
https://publications.jrc.ec.europa.eu/repository/handle/JRC54900,
10.1039/b918426k,
| Name | Country | City | Type |
|---|
This document is only visible at the Commission level.
You are not authorized to publish or distribute it outside the European Commission.
This is a public document. You can share this publication.
Datasets
| ID | Title | Public URL |
|---|
Dataset collections
| ID | Acronym | Title | Public URL |
|---|
Scripts / source codes
| Description | Public URL |
|---|
Additional supporting files
| File name | Description | File type |
|---|