Investigation of Para-sulfonatocalix[n]arenes [n = 6, 8] as Potential Chelates for 230U
Literature reports of the efficacy of para-sulfonatocalix[6]- and calix[8]-arenes as U(VI) complexants indicated that they might be useful for in vivo chelation of the novel therapeutic alpha-emitter 230U. We have studied the complexation of U(VI) with para-sulfonatocalix[6]arene and para-sulfonatocalix[8]-arene by time resolved laser induced fluorescence spectroscopy and using competition methods with
Chelex resin and 4-(2-pyridylazo)resorcinol in simplified and in biological media. New thermodynamic parameters describing the stability of U(VI)-para-sulfonatocalix[n]arene [n = 6, 8] complexes were obtained. Although the interactions are strong, the complexes do not exhibit sufficient stability to compete with carbonate ions and serum proteins for complexation of U(VI) under physiological
MONTAVON Gilles;
REPINC Urska;
APOSTOLIDIS Christos;
BRUCHERTSEIFER Frank;
ABBAS Kamel;
MORGENSTERN Alfred;
2010-01-20
ROYAL SOC CHEMISTRY
JRC54900
1477-9226,
https://publications.jrc.ec.europa.eu/repository/handle/JRC54900,
10.1039/b918426k,
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