There is the need to integrate existing dose-response data in a coherent framework for extending their domain of applicability as well as their extrapolation potential. This integration would also reduce time and cost-consuming aspects of these tests and reduce animal usage. In this work, based on data extracted from literature, we have assessed the advantages that a dynamic biology- toxicant fate coupled model for Daphnia magna could provide when assessing toxicity data, in particular, the possibility to obtain from short-term (acute) toxicity test to long-term (chronic) toxicity values and viceversa; the possibility of toxicity data reconciliation from several sources and the inherent variability of Daphnia magna populations. Implicitly in this approach is the assumption that the mode of action of the toxicant does not change after prolonged exposure.

ZALDIVAR COMENGES Jose';  BARAIBAR FENTANES Joaquin; 

2009-12-11

Publications Office of the European Union

JRC55319

978-92-79-14550-6,   

1018-5593,   

EUR 24109 EN,    OP LB-NA-24109-EN-C,   

https://publications.jrc.ec.europa.eu/repository/handle/JRC55319,   

10.2788/49365,