Investigation of para-sulfonatocalix[n]arenes [n = 6, 8] as potential chelates for 230U†

The uranophiles calix[6]- and calix[8]arene have been reported to form strong complexes with U(VI) and may be suitable for in vivo chelation of the novel therapeutic alpha emitter 230U. We have studied the complexation of U(VI) with calix[6]arene and calix[8]arene by time resolved laser induced fluorescence spectroscopy and using competition methods with chelex resin and 4-(2-pyridylazo)resorcinol in simplified and in biological media. New thermodynamic parameters describing the stability of U(VI)-calix[n]arene (n = 6, 8) complexes were obtained. Although the interactions are strong, the complexes do not exhibit sufficient stability to compete with carbonate ions and serum proteins for complexation of U(VI) under physiological conditions.

MONTAVON Gilles;  REPINC Urska;  APOSTOLIDIS Christos;  BRUCHERTSEIFER Frank;  ABBAS Kamel;  MORGENSTERN Alfred; 

2011-08-26

ROYAL SOC CHEMISTRY

JRC56357

1477-9226,   

https://publications.jrc.ec.europa.eu/repository/handle/JRC56357,   

10.1039/b918426k,