In vitro and in vivo comparison of 226Th and 213Bi-labelled radioconjugates for target alpha therapy
The novel short-lived alpha emitter 226Th (t1/2 = 31 min) decays via a rapid cascade of four alpha particles with a cumulative energy of 27.7 MeV. The single alpha emitter 213Bi (t1/2 = 31 min) emits one alpha particle of 8.4 MeV per decay. We compare the cytotoxicity of 226Th- vs. 213Bi-labelled radioconjugates towards sensitive and chemo- and radioresistant myeloid leukemia cells in vitro and in a bladder carcinoma model in vivo.
BRUCHERTSEIFER Frank;
MORGENSTERN Alfred;
FRIESEN Claudia;
ROSCHER Mareike;
MILTNER E.;
PFOST B.;
SENEKOWITSCH-SCHMIDTKE R.;
ABBAS Kamel;
APOSTOLIDIS Christos;
2010-01-27
SPRINGER
JRC56516
1619-7070,
https://publications.jrc.ec.europa.eu/repository/handle/JRC56516,
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