Title: Tracking nanoparticles optically to study their interaction with cells
Authors: GINESTE Jean-MichelMACKO PeterPATTERSON EannWHELAN Maurice
Citation: Conference Proceedings of the Society for Experimental Mechanics Series vol. 6 p. 307-310
Publisher: Springer New York
Publication Year: 2010
JRC N°: JRC57203
ISBN: 978-1-4419-9497-4 print
978-1-4419-9792-0 online
ISSN: 2191-5644
URI: http://link.springer.com/chapter/10.1007%2F978-1-4419-9792-0_50#
DOI: 10.1007/978-1-4419-9792-0_50
Type: Articles in periodicals and books
Abstract: Nanoparticles are by definition too small to be visible in an optical microscope and devices such as scanning electron microscopes must be used to resolve them. However electron beams quickly lead to cell death and so it is difficult to study the interaction of nanoparticles with living cells in order to establish whether such interactions could be damaging to the cell. A simple modification to a conventional inverted optical microscope is proposed here which renders the location of nanoparticles readily apparent and permits tracking of them in three-dimensions. Particles in the range 100nm to 500nm have been tracked with a temporal resolution of 200ms. The technique, although motivated by the desire to study the interaction of nanoparticles with cells, has a wide range of potential applications in the fields of food processing, pharmaceuticals and nano-biotechnology.
JRC Directorate:Institute for Health and Consumer Protection Historical Collection

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