Implementation and Enforcement of the 3Rs Principle in the Field of Transgenic Animals used for Scientific Purposes - Report and Recommendations of the BfR Expert Workshop, May 18-20, 2009, Berlin, Germany

The number of laboratory animals used for scientific and other purposes has been steadily rising during recent years. The growing use of transgenic animals is a major contributory factor to this trend. The Federal Institute for Risk Assessment (BfR) in Berlin, Germany invited experts from Germany and Europe to evaluate the current status and value of transgenic animal models and to identify ways to curtail their increasing use. For the purposes of this report, transgenic animals are defined as genetically modified organisms in which either genes have been selectively inactivated or xenogenous genetic material has been incorporated into their genome. Starting at May 18, 53 experts gathered at the BfR to join a three day workshop to discuss and evaluate alternatives to the use of transgenic animals for scientific purposes, and to identify important areas of future research related to this topic. Discussions were focused on opportunities and strategies to reduce the growing number of transgenic laboratory animals. Here, the so-called ¿3Rs principle¿ that seeks to replace, reduce or refine animal experiments, constituted the basis and frame of the discussions.

KRETLOW Ariane;  BUTZKE Daniel;  GOETZ Mario E.;  GRUNE Barbara;  HALDER Maria;  HENKLER Frank;  LIEBSCH Manfred;  NOBILING Rainer;  OELGESCHLAEGER Michael;  REIFENBERG Kurt;  SCHAEFER Bernd;  SEILER Andrea;  LUCH Andreas; 

2010-07-14

SPEKTRUM AKAD VERLAG

JRC57692

0946-7785,