Protein-Nanoparticle Interaction: Identification of the Ubiquitin-Gold Nanoparticle Interaction Site
We demonstrated that it is possible to identify the protein-nanoparticle interaction site at amino acid scale in solution. Using NMR, chemical shift perturbation analysis, and dynamic light scattering we have identified a specific domain of human ubiquitin that interacts with gold nanoparticles. This method allows a detailed structural analysis of proteins absorbed onto surfaces of nanoparticles in physiological
conditions and it will provide much needed experimental data for better modelling and prediction of protein-nanopartide interactions.
CALZOLAI Luigi;
FRANCHINI Fabio;
GILLILAND Douglas;
ROSSI Francois;
2010-09-08
AMER CHEMICAL SOC
JRC58386
1530-6984,
https://publications.jrc.ec.europa.eu/repository/handle/JRC58386,
10.1021/nl101746v,
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