ECVAM Technical Report on the Status of Alternative Methods for Cosmetics Testing (2008-2009)
The ECVAM technical report presents the progress made in the development and validation of alternative methods for the human health effects relevant to the Cosmetics Directive. It provides an update on the activities described by ECVAM in 2005 , 2006 and 2007 .
The report intends to present the latest scientific and technical developments in the field during 2008-2009. As required by Directive 2003/15/EC, the seventh amendment to Directive 76/768/EEC, developments in refinement and reduction methods are also described (EU, 2003).
Most successes in the development of alternative methods are in acute local toxicity and short-term testing, such as e.g. skin and eye irritation/corrosion, phototoxicity and skin penetration The test methods consuming a high number of animals, however, are in long-term testing and systemic toxicity, such as e.g. reproductive toxicity and repeated dose toxicity. In these complex fields, several research initiatives are ongoing. However full replacement approaches are still lacking.
ZUANG Valerie;
VIEGAS BARROSO Joao Filipe;
BREMER Susanne;
CASATI Silvia;
CERIDONO Mara;
COECKE Sandra;
CORVI Raffaella;
ESKES Chantra;
KINSNER-OVASKAINEN Agnieszka;
PELLIZZER Cristian;
PRIETO PERAITA Maria Del Pilar;
WORTH Andrew;
KREYSA Joachim;
2010-06-16
Publications Office of the European Union
JRC58991
978-92-79-16021-9,
1018-5593,
EUR 24413 EN,
OP LB-NA-24413-EN-C,
https://publications.jrc.ec.europa.eu/repository/handle/JRC58991,
10.2788/99101,
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