Please use this identifier to cite or link to this item:
Full metadata record
|dc.contributor.author||PRIETO PERAITA Maria Del Pilar||en_GB|
|dc.identifier.citation||ALTEX-ALTERNATIVES TO ANIMAL EXPERIMENTATION vol. 28 no. 2/11 p. 95-102||en_GB|
|dc.description.abstract||Regulatory information requirements for pesticides call for submission of acute systemic toxicity data for up to three different exposure routes (oral, dermal, inhalation) for both active ingredients and formulated products. Similar multi-route testing is required in the European Union and elsewhere for industrial chemicals. To determine the value of acute toxicity testing by more than one route, oral-dermal and oral-inhalation concordances among regulatory classifications were examined for large data sets of chemicals and pesticide active ingredients. Across all sectors examined, oral acute toxicity classifications for pure/active substances were more severe than those derived from dermal data in more than 98% of cases, which calls into question the value of routine dermal route testing for acute toxicity. Oral classifications were equivalent to or more severe than for the inhalation route for 83% of industrial chemicals and for 48% of pesticides examined.||en_GB|
|dc.description.sponsorship||JRC.I.2-Validation of Alternative Methods||en_GB|
|dc.publisher||SPEKTRUM AKAD VERLAG||en_GB|
|dc.title||Examining the regulatory value of multi-route mammalian acute systemic toxicity studies||en_GB|
|dc.type||Articles in periodicals and books||en_GB|
|JRC Directorate:||Institute for Health and Consumer Protection Historical Collection|
Files in This Item:
There are no files associated with this item.
Items in repository are protected by copyright, with all rights reserved, unless otherwise indicated.