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dc.contributor.authorSEIDLE Troyen_GB
dc.contributor.authorPRIETO PERAITA Maria Del Pilaren_GB
dc.contributor.authorBULGHERONI Annaen_GB
dc.date.accessioned2012-04-17T19:57:54Z-
dc.date.available2011-06-15en_GB
dc.date.available2012-04-17T19:57:54Z-
dc.date.created2011-05-24en_GB
dc.date.issued2011en_GB
dc.date.submitted2010-07-08en_GB
dc.identifier.citationALTEX-ALTERNATIVES TO ANIMAL EXPERIMENTATION vol. 28 no. 2/11 p. 95-102en_GB
dc.identifier.issn1868-596Xen_GB
dc.identifier.urihttp://altweb.jhsph.edu/altex/28_2/index.htmlen_GB
dc.identifier.urihttp://publications.jrc.ec.europa.eu/repository/handle/JRC59541-
dc.description.abstractRegulatory information requirements for pesticides call for submission of acute systemic toxicity data for up to three different exposure routes (oral, dermal, inhalation) for both active ingredients and formulated products. Similar multi-route testing is required in the European Union and elsewhere for industrial chemicals. To determine the value of acute toxicity testing by more than one route, oral-dermal and oral-inhalation concordances among regulatory classifications were examined for large data sets of chemicals and pesticide active ingredients. Across all sectors examined, oral acute toxicity classifications for pure/active substances were more severe than those derived from dermal data in more than 98% of cases, which calls into question the value of routine dermal route testing for acute toxicity. Oral classifications were equivalent to or more severe than for the inhalation route for 83% of industrial chemicals and for 48% of pesticides examined.en_GB
dc.description.sponsorshipJRC.I.2-Validation of Alternative Methodsen_GB
dc.format.mediumPrinteden_GB
dc.languageENGen_GB
dc.publisherSPEKTRUM AKAD VERLAGen_GB
dc.relation.ispartofseriesJRC59541en_GB
dc.titleExamining the regulatory value of multi-route mammalian acute systemic toxicity studiesen_GB
dc.typeArticles in periodicals and booksen_GB
JRC Directorate:Institute for Health and Consumer Protection Historical Collection

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