Title: Cardiotoxicity testing using pluripotent stem cell‐derived human cardiomyocytes and state‐of‐the‐art bioanalytics: a review
Authors: MANDENIUS CARL-FREDERIKSTEEL DANIELANOOR FOZIAMEYER THOMASHEINZELE ELMARASP JULIAARAIN SARINAKRAUSHAAR UDOBREMER SUSANNECLASS REINERSARTIPY PETER
Citation: JOURNAL OF APPLIED TOXICOLOGY vol. 31 no. 3 p. 191-205
Publisher: JOHN WILEY & SONS LTD
Publication Year: 2011
JRC N°: JRC62288
ISSN: 0260-437X
URI: http://onlinelibrary.wiley.com/doi/10.1002/jat.1663/abstract
http://publications.jrc.ec.europa.eu/repository/handle/JRC62288
DOI: 10.1002/jat.1663
Type: Articles in periodicals and books
Abstract: In this article, recent progress in cardiotoxicity testing based on the use of immortalized cell lines or human embryonic stem cell (hESC) derived cardiomyocytes in combination with state‐of‐the‐art bioanalytical methods and sensors is reviewed. The focus is on hESC‐derived cells and their refinement into competent testing cells, but the access and utility of other relevant cell types are also discussed. Recent developments in sensor techniques and bioanalytical approaches for measuring critical cardiotoxicity parameters are highlighted, together with aspects of data evaluation and validation. Finally, recommendations for further research are given.
JRC Directorate:Health, Consumers and Reference Materials

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