Full metadata record
DC FieldValueLanguage
dc.contributor.authorWORTH Andrewen_GB
dc.contributor.authorLAPENNA SILVIAen_GB
dc.contributor.authorSERAFIMOVA ROSITSAen_GB
dc.date.accessioned2013-03-22T01:01:30Z-
dc.date.available2013-03-21en_GB
dc.date.available2013-03-22T01:01:30Z-
dc.date.created2012-11-06en_GB
dc.date.issued2013en_GB
dc.date.submitted2011-01-11en_GB
dc.identifier.isbn978-1-62703-058-8en_GB
dc.identifier.urihttp://www.springer.com/biomed/pharmaceutical+science/book/978-1-62703-058-8en_GB
dc.identifier.urihttp://publications.jrc.ec.europa.eu/repository/handle/JRC62874-
dc.description.abstractIn this chapter, a range of computational tools for applying (Q)SAR and grouping/read-across methods are described, and their integrated use in the computational assessment of genotoxicity is illustrated through the application of selected tools to two case-study compounds - 2-amino-9H-pyrido[2,3-b]indole (AaC) and 2-aminoacetophenone (2-AAP). The first case study compound (AaC) is an environment pollutant and a food contaminant that can be formed during the cooking of protein-rich food. The second case study compound (2-AAP) is a naturally occurring compound in certain foods and also proposed for use as a flavouring agent. The overall aim is to describe and illustrate a possible way of combining different information sources and software tools for genotoxicity and metabolism prediction by means of a simple stepwise approach. The chapter is aimed at researchers and assessors who have a basic knowledge of computational toxicology and some familiarity with the practical use of computational tools. The emphasis is on how to evaluate the data generated by multiple tools, rather than the practical use of any specific tool.en_GB
dc.description.sponsorshipJRC.I.5-Systems Toxicologyen_GB
dc.format.mediumPrinteden_GB
dc.languageENGen_GB
dc.publisherSpringer Science+Business Mediaen_GB
dc.relation.ispartofseriesJRC62874en_GB
dc.titleQSAR and Metabolic Assessment Tools in the Assessment of Genotoxicityen_GB
dc.typeArticles in periodicals and booksen_GB
dc.identifier.doi10.1007/978-1-62703-059-5_6en_GB
JRC Directorate:Institute for Health and Consumer Protection Historical Collection

Files in This Item:
There are no files associated with this item.


Items in repository are protected by copyright, with all rights reserved, unless otherwise indicated.