Title: In vitro toxic effects of metal compounds on kinetic traits and ultrastructure of rabbit spermatozoa
Authors: CASTELLINI CESAREMOURVAKI EVANGELIASARTINI BARBARACARDINALI RAFFAELLAMORETTI ELENACOLLODEL GIULIAFORTANER TORRENT SALVADORSABBIONI ENRICORENIERI TOMMASO
Citation: REPRODUCTIVE TOXICOLOGY vol. 27 no. 1 p. 46-54
Publisher: PERGAMON-ELSEVIER SCIENCE LTD
Publication Year: 2009
JRC N°: JRC63875
ISSN: 0890-6238
URI: https://www.sciencedirect.com/science/article/pii/S0890623808003651?via%3Dihub
http://publications.jrc.ec.europa.eu/repository/handle/JRC63875
DOI: 10.1016/j.reprotox.2008.12.003
Type: Articles in periodicals and books
Abstract: Metal compounds have been associated with male reproductive toxicity in vivo. The aim of the present study was to investigate the in vitro effects of 20 metal compounds using rabbit ejaculated spermatozoa as a study model for spermiotoxicity. Five of the metals tested (arsenic, cadmium, chromium, mercury and vanadium) reduced sperm motility and curvilinear velocity. Ultrastructural analyses revealed three types of damage to sperm head membranes in relation to the metal used: acrosome breakage with formation of various sized microvesicles (arsenic, cadmium, mercury and platinum); a large round hole (arsenic, cadmium and chromium), and numerous folds in the acrosome membrane (vanadium). The vanadium compound, followed by chromium and mercury compounds, determined a higher number of damaged spermatozoa. In conclusion, all the studied metal compounds, at levels higher than 1M, may reduce sperm kinetic characteristics and probably fertilizing capacity by triggering specific morphological damages to the head and/or by inhibiting motility
JRC Directorate:Health, Consumers and Reference Materials

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