Treatment of early and established Cryptococcus neoformans infection with radiolabeled antibodies in immunocompetent mice
We investigated the utility of radioimmunotherapy (RIT) in early and established cryptococcal infection in immunocompetent
mice. RIT with 213Bi-18B7 antibody completely eliminated fungus from mouse lungs and brains for early infection, while 188Re-
18B7 significantly reduced CFU in the lungs or both lungs and brains during early and established infection, respectively. The
results point to the independence of RIT of the immune status of the host, which is encouraging for translation of this strategy
into the clinic.
JIANG Z.;
BRYAN R. A.;
MORGENSTERN Alfred;
BRUCHERTSEIFER Frank;
CASADEVALL Arturo;
DADACHOVA E.;
2012-02-14
AMER SOC MICROBIOLOGY
JRC65534
0066-4804,
https://publications.jrc.ec.europa.eu/repository/handle/JRC65534,
10.1128/AAC.00473-11,
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