Weak estrogenic transcriptional activities of Bisphenol A and Bisphenol S
In 2011, the European Commission has restricted the use of Bisphenol A in plastic infant feeding bottles.
In a response to this restriction, Bisphenol S is now often used as a component of plastic substitutes for
the production of babybottles. One of the major concerns leading to the restriction of Bisphenol A was its
weak estrogenic activity. By using two highly standardised transactivation assays, we could demonstrate
that the estrogenic activity of Bisphenol A and Bisphenol S is of a comparable potency. Furthermore, some
insights about the structure-activity relationships of these two chemicals and their metabolites could be
gained from in silico predictions of their relative estrogen receptor-binding affinities and their liver
phase-I biotransformation.
GRIGNARD Elise;
BREMER Susanne;
LAPENNA Silvia;
2012-07-09
PERGAMON-ELSEVIER SCIENCE LTD
JRC65672
0887-2333,
http://www.sciencedirect.com/science/article/pii/S0887233312000847,
https://publications.jrc.ec.europa.eu/repository/handle/JRC65672,
10.1016/j.tiv.2012.03.013,
Additional supporting files
| File name | Description | File type | |
|---|
