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Title: | Weak estrogenic transcriptional activities of Bisphenol A and Bisphenol S |
Authors: | GRIGNARD ELISE; BREMER Susanne; LAPENNA SILVIA |
Citation: | TOXICOLOGY IN VITRO vol. 26 no. 5 p. 727–731 |
Publisher: | PERGAMON-ELSEVIER SCIENCE LTD |
Publication Year: | 2012 |
JRC N°: | JRC65672 |
ISSN: | 0887-2333 |
URI: | http://www.sciencedirect.com/science/article/pii/S0887233312000847 http://publications.jrc.ec.europa.eu/repository/handle/JRC65672 |
DOI: | 10.1016/j.tiv.2012.03.013 |
Type: | Articles in periodicals and books |
Abstract: | In 2011, the European Commission has restricted the use of Bisphenol A in plastic infant feeding bottles. In a response to this restriction, Bisphenol S is now often used as a component of plastic substitutes for the production of babybottles. One of the major concerns leading to the restriction of Bisphenol A was its weak estrogenic activity. By using two highly standardised transactivation assays, we could demonstrate that the estrogenic activity of Bisphenol A and Bisphenol S is of a comparable potency. Furthermore, some insights about the structure-activity relationships of these two chemicals and their metabolites could be gained from in silico predictions of their relative estrogen receptor-binding affinities and their liver phase-I biotransformation. |
JRC Directorate: | Institute for Health and Consumer Protection Historical Collection |
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