Title: Positive plus negative feedback loops as an energetic efficient control in molecular systems
Citation: Book of Abstracts : ECCS'11 Vienna p. 138
Publisher: Medical University of Viena
Publication Year: 2011
JRC N°: JRC65766
ISBN: 978-3-85409-613-9
URI: http://publications.jrc.ec.europa.eu/repository/handle/JRC65766
Type: Articles in periodicals and books
Abstract: Many biological oscillators consist of a positive plus a negative feedback loop even though a negative feedback loop is enough to generate oscillations. In this work, we have analyzed from the point of view of the divergence of the system and, and hence, of the variation of total energy in the system, the advantages that the addition of a new positive loop may provide in terms of diminution of energy consumption to maintain sustained oscillations. We have compared the values of the divergence for negative, negative-plus-negative and negative-plus-positive feedback oscillator models. Finally, as an example, we have analysed the cyanobacteria circadian oscillator model that has been reproduced in vitro using three proteins: KaiA, KaiB and KaiC plus ATP.
JRC Directorate:Institute for Health and Consumer Protection Historical Collection

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