Modelling in vitro cell-based assays experiments: Cell population dynamics
We have developed an integrated model that couples a fate model with a cell growth model and a toxic effect model to analyze the dynamics of cell populations when subject to a toxicant in cell-based assays experiments. The model has been used to analyze A549 cytotoxicity assays by simulating the population dynamics and comparing with experimental data. This approach opens a new way of analyzing in vitro experiments and offers the possibility of extrapolating the values obtained to calculate in vivo human toxicology thresholds.
ZALDIVAR COMENGES Jose';
WAMBAUGH John;
JUDSON Richard;
2021-10-19
ELSEVIER BV
JRC66473
0167-8892 (online),
https://publications.jrc.ec.europa.eu/repository/handle/JRC66473,
10.1016/B978-0-444-59396-2.00004-3 (online),
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