Lipophilic Silver Nanoparticles and Their Polymeric Entrapment into Targeted-PEG-Based Micelles for the Treatment of Glioblastoma
A simple method for the synthesis of lipophilic Ag NPs have been developed. The coated Ag NPs have been entrapped into a FDA-approved and targetable PEG-based polymeric nanoparticles, and this nanocarrier has been conjugated with the peptide chlorotoxin. Uptake experiments have shown a cell-specific recognition of the Ag-1-PNPs-Cltx on U87MG cell lines in comparison to Balb/3T3. The uptake of Ag into the cells was quantified and an interesting cytotoxic effect (IC50 = 45 μM) has been found on glioblastoma cell lines.
LOCATELLI Erica;
BROGGI Francesca;
PONTI Jessica;
MARMORATO Patrick;
FRANCHINI Fabio;
LENA Stefano;
COMES FRANCHINI Mauro;
2012-07-06
WILEY-BLACKWELL
JRC67965
0935-9648,
http://onlinelibrary.wiley.com/doi/10.1002/adhm.201100047/abstract,
https://publications.jrc.ec.europa.eu/repository/handle/JRC67965,
10.1002/adhm.201100047,
Additional supporting files
| File name | Description | File type | |
|---|
