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http://publications.jrc.ec.europa.eu/repository/handle/JRC67965| Title: | Lipophilic Silver Nanoparticles and Their Polymeric Entrapment into Targeted-PEG-Based Micelles for the Treatment of Glioblastoma |
| Authors: | LOCATELLI Erica; BROGGI Francesca; PONTI Jessica; MARMORATO Patrick; FRANCHINI Fabio; LENA Stefano; COMES FRANCHINI Mauro |
| Citation: | ADVANCED MATERIALS vol. 1 no. 3 p. 342-347 |
| Publisher: | WILEY-BLACKWELL |
| Publication Year: | 2012 |
| JRC N°: | JRC67965 |
| ISSN: | 0935-9648 |
| URI: | http://onlinelibrary.wiley.com/doi/10.1002/adhm.201100047/abstract http://publications.jrc.ec.europa.eu/repository/handle/JRC67965 |
| DOI: | 10.1002/adhm.201100047 |
| Type: | Articles in periodicals and books |
| Abstract: | A simple method for the synthesis of lipophilic Ag NPs have been developed. The coated Ag NPs have been entrapped into a FDA-approved and targetable PEG-based polymeric nanoparticles, and this nanocarrier has been conjugated with the peptide chlorotoxin. Uptake experiments have shown a cell-specific recognition of the Ag-1-PNPs-Cltx on U87MG cell lines in comparison to Balb/3T3. The uptake of Ag into the cells was quantified and an interesting cytotoxic effect (IC50 = 45 μM) has been found on glioblastoma cell lines. |
| JRC Directorate: | Institute for Health and Consumer Protection Historical Collection |
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