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dc.contributor.authorFABBRI MARCOen_GB
dc.contributor.authorURANI Chiaraen_GB
dc.contributor.authorSACCO Maria-Graziaen_GB
dc.contributor.authorPROCACCIANTI Claudioen_GB
dc.contributor.authorGRIBALDO Lauraen_GB
dc.date.accessioned2012-07-07T00:00:57Z-
dc.date.available2012-07-06en_GB
dc.date.available2012-07-07T00:00:57Z-
dc.date.created2012-05-14en_GB
dc.date.issued2012en_GB
dc.date.submitted2011-12-06en_GB
dc.identifier.citationALTEX-ALTERNATIVES TO ANIMAL EXPERIMENTATION vol. 29 no. 2 p. 173-182en_GB
dc.identifier.issn1868-596Xen_GB
dc.identifier.urihttp://www.altex.ch/en/index.html?id=16&aid=5en_GB
dc.identifier.urihttp://publications.jrc.ec.europa.eu/repository/handle/JRC68093-
dc.description.abstractCadmium is a metal known to be toxic and carcinogenic, but its mechanism of action remains to be fully elucidated. We investigated the gene expression modulation in Human hepatoma cell line HepG2 after exposure to 2 µm and 10 µm cadmium using Agilent microarray. Furthermore, we evaluated the microRNA modulation after exposure to 10 µm Cd Low Density Array. At the low concentration a small number of genes are regulated and belongs to metallothionein family. At the higher concentration the pathway enrichment analysis for upregulated genes shows high numbers of pathways correlated to cancer, whereas the down regulated genes are enriched on pathways correlated to liver activity. A large percentage of regulated microRNAs belong to the let-7 family that has been described having oncosuppressor functions. Several pathways connected to cancer are regulated at the transcription level, and miRNAs have a potential impact on the modulation of this regulation.en_GB
dc.description.sponsorshipJRC.I.3-Molecular Biology and Genomicsen_GB
dc.format.mediumPrinteden_GB
dc.languageENGen_GB
dc.publisherSPEKTRUM AKAD VERLAGen_GB
dc.relation.ispartofseriesJRC68093en_GB
dc.titleWhole Genome Analysis and MicroRNAs Regulation in HepG2 Cells Exposed to Cadmiumen_GB
dc.typeArticles in periodicals and booksen_GB
JRC Directorate:Institute for Health and Consumer Protection Historical Collection

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