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dc.contributor.authorRIZVI S.m.a.en_GB
dc.contributor.authorALLEN B.j.en_GB
dc.contributor.authorLEE C.s.en_GB
dc.contributor.authorBRUCHERTSEIFER Franken_GB
dc.contributor.authorMORGENSTERN Alfreden_GB
dc.contributor.authorAPOSTOLIDIS Christosen_GB
dc.contributor.authorCLARKE R.a.en_GB
dc.date.accessioned2012-10-24T00:03:42Z-
dc.date.available2012-10-15en_GB
dc.date.available2012-10-24T00:03:42Z-
dc.date.created2012-06-18en_GB
dc.date.issued2012en_GB
dc.date.submitted2012-04-03en_GB
dc.identifier.citationIMMUNOTHERAPY vol. 4 no. 5 p. 1-6en_GB
dc.identifier.issn1750-743Xen_GB
dc.identifier.urihttp://www.futuremedicine.com/doi/abs/10.2217/imt.12.42?journalCode=imten_GB
dc.identifier.urihttp://publications.jrc.ec.europa.eu/repository/handle/JRC70139-
dc.description.abstractTumour growth requires development of new blood vessels – a process known as angiogenesis. The anti-angiogenic monoclonal antibody Bevacizumab (BZ), which targets vascular endothelial growth factor (VEGF), is now part of the standard treatment for advanced colorectal cancer. Castrate resistant prostate cancers also express VEGF but are only marginally responsive to BZ alone or in combination with chemotherapy. Targeted alpha-radioimmunotherapy (TAT) is an emerging technology that can safely enhance immunotherapy for improved cancer control. TAT targeting can be further enhanced through orthotopic delivery. In this preliminary study we investigate orthotopic TAT for the control of early-stage prostate cancer PC3 xenografts using alpha radio-labelled BZ (213Bi-BZ). Results indicate that orthotopic administration of 213Bi- BZ greatly improves the early control of organ confined prostate cancer compared to BZ alone (P<0.01).en_GB
dc.description.sponsorshipJRC.E.5-Nuclear chemistryen_GB
dc.format.mediumPrinteden_GB
dc.languageENGen_GB
dc.publisherFUTURE MEDICINE LTDen_GB
dc.relation.ispartofseriesJRC70139en_GB
dc.titleOrthotopic administration of 213Bi-Bevacizumab inhibits progression of PC3 xenografts in the prostateen_GB
dc.typeArticles in periodicals and booksen_GB
JRC Directorate:Nuclear Safety and Security

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