Proficiency testing programs for Alzheimer's disease cerebrospinal fluid biomakers
Cerebrospinal fluid (CSF) biomarkers are increasingly used for diagnosis of Alzheimer’s disease in research, clinical trials and in clinical settings. As for other biochemical measurements, variability between laboratories for these biomarkers may be monitored by proficiency testing programs, where participating laboratories use their local routine methods to analyze test samples shipped from a central laboratory. In this review we summarize the results from the last years’ pilot proficiency programs and describe the ongoing standardization efforts in this area. Global proficiency testing for CSF biomarkers is now fully established. It will continue to play an important part in the standardization of measurements that is a prerequisite for the broad-scale implementation of CSF biomarkers.
MATTSSON Niklas;
ANDREASSON Ulf;
CARRILLO Maria;
PERSSON Staffan;
SHAW Leslie;
ZEGERS Ingrid;
ZETTERBERG Henrik;
BLENNOW Kaj;
2013-04-30
FUTURE MEDICINE LTD
JRC71038
1752-0363,
http://www.futuremedicine.com/doi/abs/10.2217/bmm.12.41,
https://publications.jrc.ec.europa.eu/repository/handle/JRC71038,
10.2217/BMM.12.41,
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