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|Title:||Training needs for toxicity testing in the 21st century: a survey-informed analysis|
|Authors:||LAPENNA SILVIA; GABBERT SILKE; WORTH ANDREW|
|Citation:||ATLA-ALTERNATIVES TO LABORATORY ANIMALS vol. 40 p. 313-320|
|Type:||Articles in periodicals and books|
|Abstract:||Current and future training needs on the use of alternative methods in predictive toxicology, including new approaches based on mode of action (MOA) and adverse outcome pathway (AOP) concepts, are expected to evolve rapidly. In order to gain insight into stakeholder preferences for training, the JRC conducted a single-question survey aiming at collecting informed views on current and evolving training needs. The survey was sent to experts in regulatory agencies, industry, national research organisations, NGOs, consultancies and regulatory agencies. Stakeholder responses were evaluated by means of qualitative data analysis. Overall, we identified a set of training topics that relate both to general background information and to training needs for applying alternative testing methods. For the use of in silico methods, in particular, stakeholders emphasised the need for training on data integration and evaluation in order to increase confidence in applying these methods for regulatory purposes. Our findings support the conclusion that the development of well-targeted and tailor-made training opportunities that inform about the usefulness of various alternative methods, in particular those that offer experience of practical applications of in silico methods, deserves more attention. This should be complemented by transparent information and guidance on the interpretation of the outcomes from using those methods and software tools.|
|JRC Directorate:||Health, Consumers and Reference Materials|
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