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dc.contributor.authorWOJCIK Andrzejen_GB
dc.contributor.authorOBE Gunteren_GB
dc.contributor.authorLISOWSKA H.en_GB
dc.contributor.authorCZUB Joannaen_GB
dc.contributor.authorNIEVAART Sanderen_GB
dc.contributor.authorMOSS Raymonden_GB
dc.contributor.authorHUISKAMP R.en_GB
dc.contributor.authorSAUERWEIN Wolfgangen_GB
dc.date.accessioned2012-08-03T00:01:04Z-
dc.date.available2012-08-02en_GB
dc.date.available2012-08-03T00:01:04Z-
dc.date.created2012-07-30en_GB
dc.date.issued2012en_GB
dc.date.submitted2012-05-25en_GB
dc.identifier.citationJOURNAL OF RADIOLOGICAL PROTECTION vol. 32 no. 3 p. 261-274en_GB
dc.identifier.issn0952-4746en_GB
dc.identifier.urihttp://iopscience.iop.org/0952-4746/32/3/261/en_GB
dc.identifier.urihttp://publications.jrc.ec.europa.eu/repository/handle/JRC71645-
dc.description.abstractCells exposed to thermal neutrons are simultaneously damaged by radiations with high and low linear energy transfer (LET). A question relevant for the assessment of risk of exposure to a mixed beam is whether the biological effect of both radiation types is additive or synergistic. The aim of the present investigation was to calculate if the high and low LET components of a thermal neutron field interact when damaging cells. Human peripheral blood lymphocytes were exposed to neutrons from the HB11 beam at the Institute for Energy and Transport, Petten, Netherlands, in a 37°C water phantom at varying depths, where the mix of high and low LET beam components differs. Chromosomal aberrations were analysed and the relative biological effectiveness (RBE) values as well as the expected contribution of neutrons and photons to the aberration yield were calculated based on a dose response of aberrations in lymphocytes exposed to 60Co gamma radiation. The RBE for 10 dicentrics per 100 cells was 3 for mixed beam and 7.2 for protons. For 20 dicentrics per 100 cells the respective values were 2.4 and 5.8. The results indicate that for this endpoint there is no synergism between the high and low LET radiation.en_GB
dc.description.sponsorshipJRC.F.6-Energy systems evaluationen_GB
dc.format.mediumPrinteden_GB
dc.languageENGen_GB
dc.publisherIOP PUBLISHING LTDen_GB
dc.relation.ispartofseriesJRC71645en_GB
dc.titleChromosomal aberrations in peripheral blood lymphocytes exposed to a mixed beam of low energy neutrons and gamma radiationen_GB
dc.typeArticles in periodicals and booksen_GB
dc.identifier.doi10.1088/0952-4746/32/3/261en_GB
JRC Directorate:Energy, Transport and Climate

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