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dc.contributor.authorJOHANNING Karlaen_GB
dc.contributor.authorHANCOCK G.en_GB
dc.contributor.authorESCHER Beateen_GB
dc.contributor.authorADEKOLA Adelbayoen_GB
dc.contributor.authorBERNHARDT Maryjoen_GB
dc.contributor.authorCOWAN-ELLSBERRY Christinaen_GB
dc.contributor.authorDOMORADZKI Jeanen_GB
dc.contributor.authorDYER Scotten_GB
dc.contributor.authorEICKHOFF Curtisen_GB
dc.contributor.authorEMBRY Michelleen_GB
dc.contributor.authorERHARDT Sueen_GB
dc.contributor.authorFITZSIMMONS Patricken_GB
dc.contributor.authorHALDER Mariaen_GB
dc.contributor.authorHILL Jamesen_GB
dc.contributor.authorHOLDEN Den_GB
dc.contributor.authorJOHNSON Rebeccaen_GB
dc.contributor.authorRUTISHAUSER Sibylleen_GB
dc.contributor.authorSEGNER Helmuten_GB
dc.contributor.authorSCHULTZ Irvinen_GB
dc.contributor.authorNICHOLS Johnen_GB
dc.date.accessioned2015-05-28T09:56:57Z-
dc.date.available2013-03-05en_GB
dc.date.available2015-05-28T09:56:57Z-
dc.date.created2012-11-15en_GB
dc.date.issued2012en_GB
dc.date.submitted2012-06-07en_GB
dc.identifier.citationCurrent protocols in Toxicology vol. Supplement 53 p. 14.10.1-14.10.28en_GB
dc.identifier.urihttp://publications.jrc.ec.europa.eu/repository/handle/JRC72001-
dc.description.abstractStandard protocols are given for assessing metabolic stability in rainbow trout using the liver S9 fraction. These protocols describe the isolation of S9 fractions from trout livers, evaluation of metabolic stability using a substrate depletion approach, and expression of the result as in vivo intrinsic clearance. Additional guidance is provided on the care and handling of test animals, design and interpretation of preliminary studies, and development of analytical methods. Although initially developed to predict metabolism impacts on chemical accumulation by fish, these procedures can be used to support a broad range of scientific and risk assessment activities including evaluation of emerging chemical contaminants and improved interpretation of toxicity testing results.en_GB
dc.description.sponsorshipJRC.I.2-Public Health Policy Supporten_GB
dc.format.mediumOnlineen_GB
dc.languageENGen_GB
dc.publisherJohn Wileyen_GB
dc.relation.ispartofseriesJRC72001en_GB
dc.titleAssessment of Metabolic Stability Using the Rainbow Trout (Oncorhynchus mykiss) Liver S9 Fractionen_GB
dc.typeArticles in periodicals and booksen_GB
dc.identifier.doi10.1002/0471140856.tx1410s53en_GB
JRC Directorate:Institute for Health and Consumer Protection Historical Collection

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